Cell Systems
Advance Your 3D Blood-Brain Barrier Chips By Elevating Biological Relevance of Your Cells
3D modeling of the blood-brain barrier in a microfluidic chip using Cell Systems human primary cells has shed light onto how different types of brain cells can independently affect the brain’s response to neuroinflammation. As a more physiologically relevant model, this BBB-chip can be a new promising tool for understanding the brain.
Cell Systems
A New And Enhanced Lung Model with Cell Systems Primary Human Lung Microvascular Endothelial Cells
Elevating your insights into human cell biology requires a rethinking of each cell model. Presented in 2021, this more predictive and biologically relevant airway epithelial-endothelial model might allow scientists to better understand how our pulmonary system responses to diseases like COVID-19, COPD, asthma, cystic fibrosis and more. For the first time, scientists are co-culturing Calu-3 cells and Primary Human Lung Microvascular Endothelial Cells (from Cell Systems Cat# ACBRI 468) on flexible porous PTMC membranes to build a new airway epithelial-endothelial model that better reflects the lungs’ complexity. Many existing models involve culturing lung epithelial cells on stiff membranes, which is...
Cell Systems
Cell Systems Primary Liver Sinusoidal Endothelial Cells and Organ-Chip Performance
Organ-on-a-chips made from human primary cells have been gaining popularity in recent years as a potential research model. Not only do these systems contribute to the replacement, reduction, and refinement of animal experiments, they have also shown promises for more biologically relevant results for toxicology and drug discovery. In the paper, "Utilization of a model hepatotoxic compound, diglycolic acid, to evaluate liver Organ-Chip performance and in vitro to in vivo concordance", the Food and Drug Administration and Emulate collaborated to assess the performance of Liver-Chips made from human hepatocytes and Cell Systems' liver sinusoidal endothelial cells (ACBRI 566). These Liver Chips...
Cell Systems
In Vitro BBB Monolayer Model Explores Permeability of Nanomaterials
Transporting therapeutic drugs and agents across the blood-brain barrier (BBB) has always been a challenge for brain disease therapy. This study examines the permeability of 2D graphene nanosheets through the BBB using a popular in vitro BBB monolayer model constructed with Cell Systems primary human brain microvascular endothelial cells or hBMECs (Cat# ACBRI 376).
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